Endocrine Abstracts

Kisspeptin (metastin, HH13, KiSS-1, KiSS-1 metastasis-suppressor, KiSS-1 metastasis suppressor) is a neuropeptid that is encoded by the KISS1 gene (Messager et al., 2005). Kisspeptin-GPR54 signaling has an significant role in initiating secretion of gonadotropin-releasing hormone at puberty (K. Skorupskaite et al., 2014). Is known that kisspeptin to play a role in tumor suppression (especially in breast tissue), (E.J. M...

Short stature is a clinical sign noted in genetic syndrome.Purpose: Molecular genetic characterization of children with short stature.Objects and methods: The study involved 7 patients 3-15 yrs (3 boys and 4 girls) with short stature. Full clinical and molecular genetic research (Whole Exome or Genome Sequencing) was conducted.Results: SDS height was from -2 to -4. All patients had multiple stigmas of dysembr...

Several studies have noted that there is a connection between thyroid pathology and breast diseases.Purpose: The study was undertaken to estimate the frequency of the breasts diseases in adolescent girls with thyroid pathology.Patients and methods: The study included 2371 girls (aged 10–18 years). Thyroid diseases were diagnosed on the basis of hormonal analysis and typical picture of examination and thyroid ultrasound. Breast...

Hyperandrogenism in adolescent girls is medical and social problem, including hirsutism, seborrhea, severe acne, alopecia and hyperclitoridism.Purpose: To study the frequency and clinical peculiarities of the hyperandrogenism (HA) in adolescent girls.Patients and methods: The study included 2369 girls (aged 11–19 years). Patients were subjected to the clinical examination, ultrasound examination. Index of hyperandrogenism (HAI...

Objective: Nonclassic congenital adrenal hyperplasia (NCCAH, NCAH) or late onset congenital adrenal hyperplasia (LOCAH) is a specific type of congenital adrenal hyperplasia due to P450c21 (21-hydroxylase) deficiency with variable degrees of postnatal androgen excess, is sometimes asymptomatic (Kohn B et al. 2010; Speiser PW et al., 2010). To study the frequency NCCAH in adolescent girls.Patients and Methods: The prevention examination o...

Research indicates the relationship between beast and thyroid gland. Breast tissue contains the highest concentrations of iodine, so shortfalls in this essential mineral needs have a highly negative impact on breast tissue (R. Thompson, 2015).Purpose: The study was undertaken to estimate the frequency of the breasts diseases in adolescent girls with endemic goiter.Patients and methods: The study included 2371 girls (aged 10–18...

The impact of novel coronavirus (COVID-19) infection in adult patients with endocrine diseases is well established, with the evidence showing a link between endocrine pathology and disease severity (A. Badawi, S.G. Ryoo, 2016, J. Yang et al, 2020, S. Cianfarani, A. Brancatella, 2020). The thyroid gland and the virus infection with its associated inflammatory-immune responses are known to be engaged in complex interplay (L. Scappaticcio, et al, 2...

Diabetes mellitus is a metabolic disease that is accompanied by brain injury manifested as cognitive, emotional and vascular impairment.Purpose: To study prevalence and degree of disorders of central nervous system in children with diabetes mellitus type I (TIDM).Objects and methods: Examination of nervous system in 100 children - age 7-18 yrs [9.0-17.8] with TIDM was provided. The control group consisted of healthy children (n...

Menstrual disorders are common during adolescence. In many cases menstrual disorders associated with endocrine violations.Objective: To study the frequency menstrual disorders and endocrine violations in adolescent girls.Patients and methods: The study included 2527 adolescents- schoolgirls (aged 12–17 years, mean age was 15.5±1.9 years). The main outcome measures were menstrual disorders. Adolescent girls without menstru...

Kisspeptin (formerly known as metastin) is a neuropeptide, has an important role in initiating secretion of gonadotropin-releasing hormone at puberty. Kisspeptin hormone levels disorders cause hypogonadism or premature sexual development and sterility.Aims: The study was undertaken to research the kisspeptin level in healthy girls and adolescent girls and in girls and adolescents with gynaecological and endocrine disorders.Patients...